SCI-PUB

Sepsis

Assessment of soluble thrombomodulin and soluble endoglin as endothelial dysfunction biomarkers in seriously ill surgical septic patients: correlation with organ dysfunction and disease severity.

The study concludes that elevated levels of soluble thrombomodulin and soluble endoglin can serve as endothelial biomarkers for early diagnosis and prognostication in seriously ill surgical septic patients.

DOI: 10.1007/s00068-023-02369-8

Khan MAO, Suvvari TK, Harooni SAS, Khan AA, Anees S, Bushra

European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023-09-25

NEW

Comment on: Clinical Risk Factors for Infective Endocarditis Patients with staphylococcus Aureus Bacteremia and the Diagnostic Utility of Transesophageal Echocardiogram.

No abstract text is available for this article

DOI: 10.1016/j.cpcardiol.2023.102105

Tanisha , Turesh K, Soojal , Khenhrani RR

Current problems in cardiology, 2023-09-25

NEW

NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms.

Sepsis-induced myocardial dysfunction (SIMD) is one of the serious health-affecting problems worldwide...

DOI: 10.1016/j.biopha.2023.115497

Zhang H, Liao J, Jin L, Lin Y

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023-09-25

Neutrophil membrane engineered Panax ginseng root derived exosomes loaded miRNA 182-5p targets NOX4/Drp-1/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies.

In conclusion, this study prepared a novel engineered exosome (N-exo) and N-exo-miRNA 182-5p significantly improved ALI in sepsis via target regulation of NOX4/Drp-1/NLRP3 signal pathway, providing new ideas and methods for treatment of ALI in sepsis.

DOI: 10.1097/JS9.0000000000000789

Ma C, Liu K, Wang F, Fei X, Niu C, Li T, Liu L

International journal of surgery (London, England), 2023-09-23

Clinical implications of endotoxin activity and Polymyxin-B hemoperfusion in critically ill patients with septic cardiomyopathy: A single-center, retrospective, observational study.

In septic patients, EA was not associated with SCM. However, endotoxin removal by Polymyxin-B hemoperfusion was associated with recovery from cardiomyopathy, which was a predictor of lower 28-day mortality.

DOI: 10.1111/aor.14645

Cutuli SL, Carelli S, Cascarano L, Cicconi S, Silvestri D, Cicetti M, Vallecoccia MS, Pintaudi G, Tanzarella ES, Grieco DL, Antonelli M, De Pascale G

Artificial organs, 2023-09-23

Correction: Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021.

No abstract text is available for this article

DOI: 10.1007/s15010-023-02090-z

Skei NV, Nilsen TIL, Mohus RM, Prescott HC, Lydersen S, Solligård E, Damås JK, Gustad LT

Infection, 2023-09-23

Timing of renal replacement therapy in patients with sepsis-associated acute kidney injury: A systematic review and meta-analysis.

Early RRT may be beneficial to the 28-day short-term survival rate of patients with sepsis-associated AKI in Kidney Disease: Improving Global Outcomes stage 2 and having Sequential Organ Failure Assessment score less than or equal to 12 but has no significant effect on long-term survival, length of intensive care unit stay, the total length of hospital stay, and 28-day RRT dependence of survivors. These results still need to be confirmed by more large-scale randomised controlled studies.

DOI: 10.1016/j.aucc.2023.06.011

Wang Q, Liu F, Tao W, Qian K

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2023-09-23

Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.

BACKGROUND: Fluid overload is associated with excess mortality in septic shock...

DOI: 10.1136/bmjopen-2023-074847

Messmer A, Pietsch U, Siegemund M, Buehler P, Waskowski J, Müller M, Uehlinger DE, Hollinger A, Filipovic M, Berger D, Schefold JC, Pfortmueller CA

BMJ open, 2023-09-23

Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy.

Sepsis, a life-threatening dysregulated status of the host response to infection, can cause multiorgan dysfunction and mortality...

DOI: 10.1016/j.biopha.2023.115493

Fan Y, Guan B, Xu J, Zhang H, Yi L, Yang Z

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023-09-23

QuickStats: Sepsis-Related* Death Rates Among Persons Aged ≥65 Years, by Age Group and Sex - National Vital Statistics System, United States, 2021.

No abstract text is available for this article

DOI: 10.15585/mmwr.mm7238a5

MMWR. Morbidity and mortality weekly report, 2023-09-23

Prevention of Central Line-Associated Bloodstream Infections.

No abstract text is available for this article

DOI: 10.1056/NEJMra2213296

O'Grady NP

The New England journal of medicine, 2023-09-22

Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis.

Sepsis is a condition with high morbidity and mortality...

DOI: 10.1186/s40635-023-00548-w

Tenhunen AB, van der Heijden J, Skorup P, Maccarana M, Larsson A, Larsson A, Perchiazzi G, Tenhunen J

Intensive care medicine experimental, 2023-09-22

Effect of intravenous immunoglobulin on the outcome of children with septic shock in a PICU: a retrospective cohort study.

In children with septic shock, the use of intravenous immunoglobulin as an adjuvant therapy does not reduce in-hospital mortality.

DOI: 10.1007/s00431-023-05224-5

Huang H, Chen J, Dang H, Liu C, Huo J, Fu YQ

European journal of pediatrics, 2023-09-22

Photo Quiz: Bloodstream infection in a neutropenic patient with severe aplastic anemia.

No abstract text is available for this article

DOI: 10.1128/jcm.00566-23

Abdolrasouli A, Schelenz S

Journal of clinical microbiology, 2023-09-22

Answer to the Photo Quiz: Bloodstream infection in a neutropenic patient with severe aplastic anemia.

No abstract text is available for this article

DOI: 10.1128/jcm.00576-23

Abdolrasouli A, Schelenz S

Journal of clinical microbiology, 2023-09-22

Necrotic Lip Infection Complicated by Facial Cellulitis and Septic Thoracic Emboli in an 18-year-old Man: A Quiz.

No abstract text is available for this article

DOI: 10.2340/actadv.v103.9605

Saraux O, Fabre F, Milpied B, Cazanave C, Beylot-Barry M

Acta dermato-venereologica, 2023-09-22

Transcriptome analysis of six tissues obtained post-mortem from sepsis patients.

Septic shock is a life-threatening clinical condition characterized by a robust immune inflammatory response to disseminated infection...

DOI: 10.1111/jcmm.17938

Pinheiro da Silva F, Gonçalves ANA, Duarte-Neto AN, Dias TL, Barbeiro HV, Breda CNS, Breda LCD, Câmara NOS, Nakaya HI

Journal of cellular and molecular medicine, 2023-09-22

Resveratrol Inhibits circ_0074371-related Pathway to Alleviate Sepsis-induced Acute Kidney Injury.

Resveratrol has a protective effect on sepsis-induced acute kidney injury (AKI)...

DOI: 10.1007/s10528-023-10517-3

Zhu D, Wu X

Biochemical genetics, 2023-09-22

Risk of endocarditis among patients with coagulase-negative Staphylococcus bacteremia.

Coagulase-negative staphylococci (CoNS) are currently considered typical microorganisms causing infective endocarditis (IE) in patients with prosthetic valves...

DOI: 10.1038/s41598-023-41888-7

Ramos-Martínez A, González-Merino P, Suanzes-Martín E, la Fuente MM, Escudero-López G, Andrés-Eisenhofer A, Expósito-Palomo E, Gutierrez-Villanueva A, Diego-Yagüe I, Múñez E, Fernandez-Cruz A, Calderón-Parra J

Scientific reports, 2023-09-22

Assessment of systemic circulation using ultrasound Doppler in late onset neonatal sepsis and its clinical correlation: an observational study.

LONS is associated with alterations in cerebral, splanchnic, and renal perfusion seen as abnormal blood flow velocimetry and vascular resistance which may predispose to IVH, NEC, and AKI.

DOI: 10.1007/s40477-023-00826-z

Singh P, Verma A, Malshe N, Kallimath A, Oak G, Malviya M, Chouthai N, Suryawanshi P

Journal of ultrasound, 2023-09-21

Fluid Resuscitation and Relation to Respiratory Support Escalation in Patients with and without Pulmonary Hypertension with Sepsis.

During initial sepsis management when compared to patients without PH, patients with PH had increased instances of respiratory support escalation within 72 hours of sepsis time zero despite lower fluid resuscitation volumes.

DOI: 10.1002/phar.2879

Fronrath MJ, Hencken L, Martz CR, Kelly B, Smith ZR

Pharmacotherapy, 2023-09-21

CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis.

Sepsis-induced acute respiratory distress syndrome (ARDS) remains a major complication of death from bacterial infection...

DOI: 10.1080/08916934.2023.2259131

Zhong J, Zhang W, Zhang L, Li J, Kang L, Li X

Autoimmunity, 2023-09-20

Single-dose oral azithromycin prophylaxis in planned vaginal delivery for sepsis prevention: A systematic review and meta-analysis of randomized controlled trials.

AZI appears to be an effective preventive measure against many postpartum infections in mothers but a substantial impact on neonatal outcomes has not yet been conclusively observed.

DOI: 10.1002/ijgo.15124

Crosara LF, Orsini PVB, Eskandar K, Khalil SM, Castilhos GSF, Strahl PAM, Milbradt TL, Philip CE

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2023-09-20

Analysis of the dynamic changes in gut microbiota in patients with different severity in sepsis.

The diversity of the gut microbiota in patients with sepsis decreases dramatically during ICU stay, and there are distinct dynamic changes in gut microbiota among patients with different severity in sepsis.

DOI: 10.1186/s12879-023-08608-y

Liu Y, Guo Y, Hu S, Wang Y, Zhang L, Yu L, Geng F

BMC infectious diseases, 2023-09-20

Complete genome sequence of a human bacteremia isolate of .

The complete genome of Kalamiella piersonii clinical isolate URMC-2103A041 from human bacteremia was determined using the hybrid assembly of short- and long-read sequencing chemistry.

DOI: 10.1128/MRA.00293-23

Howard M, Maki JJ, Connelly S, Hardy DJ, Cameron A

Microbiology resource announcements, 2023-09-20

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Sepsis

Assessment of soluble thrombomodulin and soluble endoglin as endothelial dysfunction biomarkers in seriously ill surgical septic patients: correlation with organ dysfunction and disease severity.

Comment on: Clinical Risk Factors for Infective Endocarditis Patients with staphylococcus Aureus Bacteremia and the Diagnostic Utility of Transesophageal Echocardiogram.

NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms.

Neutrophil membrane engineered Panax ginseng root derived exosomes loaded miRNA 182-5p targets NOX4/Drp-1/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies.

Clinical implications of endotoxin activity and Polymyxin-B hemoperfusion in critically ill patients with septic cardiomyopathy: A single-center, retrospective, observational study.

Correction: Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021.

Timing of renal replacement therapy in patients with sepsis-associated acute kidney injury: A systematic review and meta-analysis.

Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.

Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy.

QuickStats: Sepsis-Related* Death Rates Among Persons Aged ≥65 Years, by Age Group and Sex - National Vital Statistics System, United States, 2021.

Prevention of Central Line-Associated Bloodstream Infections.

Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis.

Effect of intravenous immunoglobulin on the outcome of children with septic shock in a PICU: a retrospective cohort study.

Photo Quiz: Bloodstream infection in a neutropenic patient with severe aplastic anemia.

Answer to the Photo Quiz: Bloodstream infection in a neutropenic patient with severe aplastic anemia.

Necrotic Lip Infection Complicated by Facial Cellulitis and Septic Thoracic Emboli in an 18-year-old Man: A Quiz.

Transcriptome analysis of six tissues obtained post-mortem from sepsis patients.

Resveratrol Inhibits circ_0074371-related Pathway to Alleviate Sepsis-induced Acute Kidney Injury.

Risk of endocarditis among patients with coagulase-negative Staphylococcus bacteremia.

Assessment of systemic circulation using ultrasound Doppler in late onset neonatal sepsis and its clinical correlation: an observational study.

Fluid Resuscitation and Relation to Respiratory Support Escalation in Patients with and without Pulmonary Hypertension with Sepsis.

CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis.

Single-dose oral azithromycin prophylaxis in planned vaginal delivery for sepsis prevention: A systematic review and meta-analysis of randomized controlled trials.

Analysis of the dynamic changes in gut microbiota in patients with different severity in sepsis.

Complete genome sequence of a human bacteremia isolate of .

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